Pangaea was awarded a contract under a grant with Rush University Medical Center from the U.S. Army Medical Research and ACQ Activity, Telemedicine and Advanced Technology Research Center to continue the development for GUARDIAN (Geographic Utilization of Artificial Intelligence in Real-Time for Disease Identification and Notification). GUARDIAN is a real-time, scalable, extensible, automated, knowledge-based biological threat agent (BTA) detection and diagnosis system. The purpose of GUARDIAN is to conduct rapid analysis of multiple parameters contained in medical records collected by hospital emergency departments in real time in order to detect probable specific disease occurrence. The goal of this system is to assist clinicians in detecting potential BTAs as quickly and effectively as possible based on pre-diagnostic data in order to better respond to and mitigate the potential effects of a large-scale outbreak.